Publications and Patents:

Journal Articles:  

• Arc-modulated Radiation Therapy (AMRT): a single-arc form of Intensity-Modulated Arc Therapy, with Wang C, Tang G, Chen DZ, Earl M, and Yu C. Accepted to Physics in Medicine and Biology.
• Stochastic vs. deterministic kernel based superposition approaches for dose calculation of intensity-modulated arcs, with G. Tang, M.A Earl, C. Wang, D. Cao, C.X. Yu, and S.A. Naqvi. Physics in Medicine and Biology. 53 (2008.) 4733-4746.
• Mountain Reduction, Block Matching, and Medical Applications, with D.Z. Chen, S.X. Hu, C. Wang, and X. Wu, International Journal of Computational Geometry and Applications (IJCGA), Vol. 18, Nos. 1-2 (April 2008), 63-106.
• Leaf-sequencing for intensity-modulated arc therapy using graph algorithms, with C. Wang, D. Cao, D.Z. Chen, D.M. Shepard, and C.X. Yu. Medical Physics, Vol 35, No. 1, 2008, 61-69.
• Approximation algorithms for minimizing segments in radiation therapy, with J. Saia and M. Young, Information Professing Letters, Vol. 101, 2007, 239-244.
• New Developments in Intensity Modulated Radiation Therapy, with C. Yu, D. Shepard, M. Earl, D. Cao, C. Wang and D. Chen, an invited submission to Technology in Cancer Research and Treatment, 2006, 451-564
• An improved MLC segmentation algorithm and software for step-and-shoot IMRT delivery without tongue-and-groove error, with C. Wang, D.Z. Chen, X.S. Hu, S.A. Naqvi, X. Wu, C.X. Yu, Medical Physics. Vol 33, No. 5, 2006, pp. 1199-1212.
• Continuous Intensity Map Optimization (CIMO): A Novel Approach to Leaf Sequencing in Step and Shoot IMRT, with D. Cao, M. Earl, and D. Shepard, Medical Physics, Vol. 33, No. 4, 2006, pp. 859-867.
• Generalized Geometric Approaches for Leaf Sequencing Problems in Radiation Therapy, with D.Z. Chen, X.S. Hu, S.A. Naqvi, C. Wang, and C.X. Yu, International Journal of Computational Geometry and Applications (IJCGA), Vol. 16, No 2-3, June  2006. 175-204.
• Optimal Terrain Construction Problems and its application in intensity modulated radiation therapy, with D.Z. Chen, X.S. Hu, X. Wu, and C.X. Yu, Algorithmica, Vol. 42, No. 3-4, June 2005, pp. 265-288.
• Geometric Algorithms for Static Leaf Sequencing Problems in Radiation Therapy, with D.Z. Chen, X. S. Hu, C. Wang, and X. Wu, International Journal of Computational Geometry and Applications (IJCGA), Vol. 14, October 2004, pp. 311-339.
• A new MLC segmentation algorithm/software for step-and-shoot IMRT delivery, with C. Wang, D.Z. Chen, X. S. Hu, S.A. Naqvi, C.L. Lee, and C.X. Yu, Medical Physics, Vol. 31, No. 4, April 2004, page 695-707.
• An Optimal Algorithm for Computing Configuration Options of One-dimensional Intensity Modulated Beams, with D.Z. Chen, L. Zhang, X. Wu, and C.X. Yu, Physics in Medicine and Biology, Vol. 48, No. 15, August 2003, page 2321-2338.
• Topological Peeling and Applications, with D.Z. Chen and J. Xu, International Journal of Computational Geometry and Applications (IJCGA), Vol. 13, No. 2, April 2003, page 135-172.

Refereed Conference Articles in Computer Science:

• Coupled Path Planning, Region Optimization, and Applications in Intensity-Modulated Radiation Therapy, with D.Z. Chen and C. Wang. Lecture Notes in Computer Science, Vol.~5193, Springer Verlag, Proc of 16^th Annual European Symposium on Algorithms (ESA¡¯ 2008), pages 271-283.
• Shape Rectangularization Problems in Intensity-Modulated Radiation Therapy, with D.Z. Chen, X.S. Hu, E. Misiolek, and C. Wang, 17^th International Symposium on Algorithms and Computation (ISAAC¡¯06), 701-711.
• A Leaf Sequencing Software for Intensity-Modulated Radiation Therapy, with C. Wang, D.Z. Chen, X.S. Hu, the 19th IEEE Symposium on Computer Based Software Systems, 2006, 3-8.
• Mountain Reduction, Block Matching, and Medical Applications, with D.Z. Chen, C. Wang, and X. Wu, 21^st ACM Symposium on Computational Geometry, June 2005.
• Generalized Geometric Approaches for Leaf Sequencing Problems in Radiation Therapy, with D.Z. Chen, X.S. Hu, S.A. Naqvi, C. Wang, and C.X. Yu, 15th International Symposium on Algorithms and Computation (ISAAC 2004), December 2004.
• Geometric Algorithms for Static Leaf Sequencing Problems in Radiation Therapy, with D.Z. Chen, X. S. Hu, C. Wang, and X. Wu, Proc. of 19th ACM Symposium on Computational Geometry (SoCG03), San Diego, CA, June 2003, page 88-97.
• Optimal Terrain Construction Problems and Applications in Intensity-Modulated Radiation Therapy, with D.Z. Chen, X.S. Hu, X. Wu, and C.X. Yu, Lecture Notes in Computer Science, Vol.~2461, Springer Verlag, Proc. of the Tenth Annual European Symposium on Algorithms (ESA), Rome, Italy, September 2002, page 270-283.
• An Experimental Study and Comparison of Topological Peeling and Topological Walk, with D.Z. Chen and J. Xu, Lecture Notes in Computer Science, Vol. 2387, Springer Verlag, Proc. of the Eighth Annual International Computing and Combinatorics Conference (COCOON), Singapore, August 2002, page 456-466.
• Topological Peeling and Implementation, in Springer-Verlag, Lecture Notes in Computer Science, with D.Z. Chen and J. Xu, Vol. 2223, Proc. 12th International Symposium on Algorithms and Computations (ISAAC), page 454-466, 2001.

Refereed Conference Abstracts in Medical Physics:

• Dynamic leaf sequencing with monitor unit control, with C. Wang, G. Tang, D. Chen, C. Yu, the 50^th Annual Meeting of American Association of Physicists in Medicine (AAPM), 2008.
• Arc modulated radiation therapy, a novel method for rotational radiation therapy, with C. Wang, S. Luan, G. Tang, M. Earl, D. Chen, C. Yu, the 50^th Annual Meeting of American Association of Physicists in Medicine (AAPM), 2008.
• Is dose variation crucial for single-arc radiation therapy delivery, with G. Tang, M. Earl, C. Wang, D. Chen, C. Yu, the 50^th Annual Meeting of American Association of Physicists in Medicine (AAPM), 2008.
• Comparison of intensity-modulated radiation therapy, intensity-modulated arc therapy, and arc modulated radiation therapy, with G. Tang, M. Earl, C. Wang, D. Chen, S. Naqvi, C. Yu, the 50^th Annual Meeting of American Association of Physicists in Medicine (AAPM), 2008.
• Converting multiple-arc Intensity-modulated Arc Therapy into a single arc for efficient delivery, with G. Tang, M. Earl, S. Naqvi and C. Yu, the 49^th Annual Meeting of American Society of Therapeutic Radiology and Oncology (ASTRO), 2007.
• A dynamic dose delivery model of Gamma Knife radiosurgery, with N. Swanson, K. Li and L. Ma, the 49^th Annual Meeting of American Association of Physicists in Medicine (AAPM), 2007.
• IMAT leaf sequencing using graph algorithms, with C. Wang, D. Cao, D.Z. Chen, D.M. Shepard, and C.X. Yu, he 49^th Annual Meeting of American Association of Physicists in Medicine (AAPM), 2007.
• Dynamic Gamma Knife Radiosurgery, with N. Swanson, K. Li and L. Ma, the 8th Bi-annual Congress and Exhibition of the International Stereotactic Radiosurgery Society, 2007.
• A New Algorithm/Software for CT Measurement of Airway Wall Volume, with P. Wilkins, N. Swanson, P. Heintz, and L. Ketai, the Radiological Society of North America (RSNA) 92nd Scientific Assembly and Annual Meeting, 2006
• Patient Breathing Motion Synchronized IMAT: A New Technique for Compensating Intra Fraction Organ Motions, with C. Wang, D. Cao, D. Chen, W. D¡¯Souza, and C. Yu, the 48^th Annual Meeting of American Association of Physicists in Medicine (AAPM), 2006.
• Cntinuous Intensity Map Optimization (CIMO): A Novel Leaf Sequencing Algorithm, with D. Cao, M. Earl, and D. Shepard, 48^th Annual Meeting of American Association of Physicists in Medicine (AAPM), 2006.
• The Effect of Collimator Rotation on IMRT Treatment Planning, with P.H. Heintz, S.A. Sorensen, A.A. Jimenez, D.Z. Chen, K.D. Roedersheimer, G. Wong, the 47^th Annual Meeting of American Society of Therapeutic Radiology and Oncology (ASTRO), 2005.
• The Impact of Multileaf Collimator Rotation in IMRT Planning, with K.D. Roedersheimer, D.Z. Chen, and L. Xing, the 47^th Annual Meeting of the American Association of Physicists in Medicine (AAPM), 2005
• A Generalized MLC Segmentation Algorithm for Step-and-Shoot IMRT with no Tongue-and-Groove Error, with C. Wang C, D.Z. Chen, X.S. Hu, and C.X. Yu, the 47^th Annual Meeting of American Association of Physicists in Medicine (AAPM), 2005.
• A New MLC Segmentation Algorithm for Step and Shoot IMRT Without Tongue-and-Groove Error, with C. Wang, D.Z. Chen, X.S. Hu, S.A. Naqvi, and C.X. Yu, Forty-Sixth Annual Meeting and Technical Exhibition of the American Association of Physicists in Medicine (AAPM), Pittsburgh, PA, July 2004. Also appear in Medical Physics Special Issue for the AAPM Annual Meeting, Vol. 31, No. 6, June 2004, page 1843.
• A Study of the Impact of MLC Constraints on the Number of Segments in Step-and-Shoot IMRT Delivery, with C. Wang, D.Z. Chen, X.S. Hu, and C.X. Yu, Forty-Sixth Annual Meeting and Technical Exhibition of the American Association of Physicists in Medicine (AAPM), Pittsburgh, PA, July 2004. Also appear in Medical Physics Special Issue for the AAPM Annual Meeting, Vol. 30, No. 6, June 2004, page 1843.
• A New Leaf Sequencing Algorithm/Software for Step and Shoot IMRT, with C. Wang, S.A. Naqvi, D.Z. Chen, X.S. Hu, C.L. Lee, and C.X. Yu, Forty-Fifth Annual Meeting and Technical Exhibition of the American Association of Physicists in Medicine (AAPM), San Diego, CA, August 2003. Also appear in Medical Physics Special Issue for the AAPM Annual Meeting, Vol. 30, No. 6, June 2003, page 1404
• A New Leaf-Sequencing Algorithm for Intensity-Modulated Arc Therapy, with X. Wu, D.Z. Chen, X.S. Hu, L. Zhang, and C.X. Yu, Forty-Third Annual Meeting and Technical Exhibition of the American Association of Physicists in Medicine (AAPM), Salt Lake City, Utah, July, 2001. Also appear in Medical Physics Special Issue for the AAPM Annual Meeting, Vol. 28, No. 6, June 2001, page 1252.

    Patents and Software:

• Inventor of Provisional Patent: UNM-810, A Method of Dynamically Conforming Predefined Photon Beams to a Tumor Volume. Provisional patent is being filed by University of New Mexico Science and Technology Center.
• Co-Inventor of Single Arc Dose Painting for Precision Radiation Therapy. International patent application filed by University of Maryland School of Medicine, UMB Ref: CY-2007-044.
• Inventor of US Patent: UNND-0064-UT2: Error control in Algorithmic Approach to Step-and-Shoot Intensity Modulated Radiation Therapy (pending). 
• Inventor of US Patent 7.283,611 B1: Segmentation Algorithmic Approach to Step and-Shoot Intensity Modulated Radiation Therapy. 
• SLS software: Designed and developed the static leaf sequencing software for ``step and shoot'' intensity-modulated radiation therapy (IMRT). The software has been used clinically in the Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, MD and the Helen P. Denit Cancer Center, Montgomery General Hospital, Olney, MD.

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