@article{chao04icb,
  author        = {Dennis L. Chao and Miles P. Davenport and Stephanie Forrest and Alan S. Perelson},
  title         = {Modelling the impact of antigen kinetics on {T}-cell activation and response},
  journal       = {Immunol Cell Biol},
  volume        = 82,
  number        = 1,
  pages         = {55--61},
  address       = {Department of Computer Science, University of New Mexico,
                  Albuquerque, NM 87131, USA},
  month         = {Feb},
  year          = {2004},
  abstract      = {Cytotoxic T lymphocyte (CTL) responses are thought to be
                  important for the control of many viral and other
                  infections. Qualitative aspects of the CTL response,
                  including the epitope specificity, affinity, and clonal
                  composition, may affect the ability of T cells to mediate
                  infection control. Although it is clear that the mode of
                  introduction and the dose of antigen can affect these
                  qualitative aspects of the response, little is understood
                  of the mechanisms. We have developed an in silico model of
                  the CTL response, which we use to study the impact of
                  antigen dose, antigen kinetics and repeated antigen
                  delivery on the response. The results suggest that recent
                  observations on differences in response to killed antigen
                  can be explained simply by differences in timing of T-cell
                  activation. These findings may provide insight into how
                  different vaccination strategies can quantitatively and
                  qualitatively affect the outcome of the immune response.},
  keywords      = {2004/02/27 05:00}
}