@Article{         chao04jtb,
  author        = {Dennis L. Chao and Miles P. Davenport and Stephanie
                  Forrest and Alan S. Perelson},
  title         = {A stochastic model of cytotoxic {T} cell responses},
  journal       = {J Theor Biol},
  volume        = 228,
  number        = 2,
  pages         = {227--240},
  address       = {Department of Computer Science, University of New Mexico,
                  Albuquerque, NM 87131, USA},
  month         = {May 21},
  year          = {2004},
  abstract      = {We have constructed a stochastic stage-structured model of
                  the cytotoxic T lymphocyte (CTL) response to antigen and
                  the maintenance of immunological memory. The model follows
                  the dynamics of a viral infection and the stimulation,
                  proliferation, and differentiation of naive CD8(+) T cells
                  into effector CTL, which can eliminate virally infected
                  cells. The model is capable of following the dynamics of
                  multiple T cell clones, each with a T cell receptor
                  represented by a digit string. MHC-viral peptide complexes
                  are also represented by strings and a string match rule is
                  used to compute the affinity of a T cell receptor for a
                  viral epitope. The avidities of interactions are also
                  computed by taking into consideration the density of
                  MHC-viral peptides on the surface of an infected cell.
                  Lastly, the model allows the probability of T cell
                  stimulation to depend on avidity but also incorporates the
                  notion of an antigen-independent programmed pro...},
  keywords      = {Antigens, Viral/*immunology Human Immunologic Memory
                  Lymphocyte Activation Lymphocytic
                  Choriomeningitis/immunology Lymphocytic choriomeningitis
                  virus/immunology *Models, Immunological Support, Non-U.S.
                  Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't,
                  P.H.S. T-Lymphocytes, Cytotoxic/*immunology 2004/05/22
                  05:00},
  reference     = {0 (Antigens, Viral)}
}