@Article{	  davenport04jvi,
   author = {M. P. Davenport and R. M. Ribeiro and D. L. Chao and A. S. Perelson },
   editor = {2004/09/29 05:00},
   title = {Predicting the impact of a nonsterilizing vaccine against human immunodeficiency virus},
   journal = {J Virol},
   volume = {78},
   number = {20},
   pages = {11340-51},
   address = {Department of Haematology, Prince of Wales Hospital, and Centre for Vascular Research, University of New South Wales, Kensington, NSW, Australia.},
   month = {Oct},
   year = {2004},
   abstract = {Studies of human immunodeficiency virus (HIV) vaccines in animal models
suggest that it is difficult to induce complete protection from infection
(sterilizing immunity) but that it is possible to reduce the viral load
and to slow or prevent disease progression following infection. We have
developed an age-structured epidemiological model of the effects of a
disease-modifying HIV vaccine that incorporates the intrahost dynamics of
infection, a transmission rate and host mortality that depend on the viral
load, the possible evolution and transmission of vaccine escape mutant
viruses, a finite duration of vaccine protection, and possible changes in
sexual behavior. Using this model, we investigated the long-term outcome
of a disease-modifying vaccine and utilized uncertainty analysis to
quantify the effects of our lack of precise knowledge of various
parameters. Our results suggest that the extent of viral load reduction in
vaccinated i...},
   keywords = {*AIDS Vaccines/administration \& dosage/immunology Disease Outbreaks Disease Progression HIV/*genetics/*physiology HIV Infections/mortality/*prevention \& control/transmission/virology Human Incidence *Models, Biological Predictive Value of Tests Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S. Gov't, P.H.S. Time Factors Vaccination Viral Load 2004/11/04 09:00},
   reference = {0 (AIDS Vaccines)}
}