Automated Quality Assurance of Plain Radiographs by Rory L.P. McGuire ABSTRACT Picture Archiving and Communication Systems (PACS) are becoming prevalent in many radiology departments. However, with such a system, the radiographic image retake rate is still between 2.3% and 4.6%. At this rate, tens of millions of dollars may be wasted and diagnoses for millions of patients delayed. The goal of this research is to explore various ways to automatically qualify diagnostic radiographs based on criteria determined by radiologists. We have developed a prototype real-time radiograph quality assurance system that could significantly reduce the overall x-ray retake rate, lower public exposure to radiation, and implicitly train radiography technicians by providing instant feedback on imaging techniques. This system could also reduce time required by the patient, technician and radiologist, thereby reducing the total cost of treatment. Our system has two main parts: (1) anatomical site categorization of an image, and (2) registration, learning, and classification of an image for each anatomical site. For the first part, we use mutual information to categorize knee and chest images. For the second part, we focus on knee images. We use the Hough transform, a well-known simple edge detection algorithm; the "eigenfaces" method of calculating the principal components of a set of images and reducing the dimensionality of the search space; and a simple, nearest-neighbor supervised learning and classification algorithm. We believe our system could serve as a springboard for similar systems to qualify medical imaging data of other anatomical sites.